Regulation of secondary hair follicle cycle in cashmere goats by miR-877-3p targeting IGFBP5 gene.
J Anim Sci
; 1012023 Jan 03.
Article
in En
| MEDLINE
| ID: mdl-37777862
Cashmere goats, known for their diverse range of animal products including delectable meat, soft sheepskin, and high-quality natural fiber, offer an excellent opportunity to explore hair regeneration as they represent a heterogenous fur mammal. MicroRNAs (miRNAs) are small non-coding RNA molecules encoded by approximately 3% of mammalian genes. Remarkably, they have the ability to regulate around 30% of protein-coding genes. Given that a single miRNA can target multiple genes, they exert control over various biological functions such as metabolism, growth, development, and immunity. In this study, we found that miR-877-3p is able to regulate the expression of insulin-like growth factor binding protein 5 (IGFBP5), a key gene involved in the development of the hair follicle cycle. Investigating the regulatory role of miRNAs in the hair follicle cycle of cashmere goats provides a novel perspective for unraveling the mechanisms underlying hair follicle growth and development in mammals.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hair Follicle
/
MicroRNAs
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Anim Sci
Year:
2023
Document type:
Article
Affiliation country:
China
Country of publication:
United States