Your browser doesn't support javascript.
loading
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.
Thomas, Minta; Su, Yu-Ru; Rosenthal, Elisabeth A; Sakoda, Lori C; Schmit, Stephanie L; Timofeeva, Maria N; Chen, Zhishan; Fernandez-Rozadilla, Ceres; Law, Philip J; Murphy, Neil; Carreras-Torres, Robert; Diez-Obrero, Virginia; van Duijnhoven, Franzel J B; Jiang, Shangqing; Shin, Aesun; Wolk, Alicja; Phipps, Amanda I; Burnett-Hartman, Andrea; Gsur, Andrea; Chan, Andrew T; Zauber, Ann G; Wu, Anna H; Lindblom, Annika; Um, Caroline Y; Tangen, Catherine M; Gignoux, Chris; Newton, Christina; Haiman, Christopher A; Qu, Conghui; Bishop, D Timothy; Buchanan, Daniel D; Crosslin, David R; Conti, David V; Kim, Dong-Hyun; Hauser, Elizabeth; White, Emily; Siegel, Erin; Schumacher, Fredrick R; Rennert, Gad; Giles, Graham G; Hampel, Heather; Brenner, Hermann; Oze, Isao; Oh, Jae Hwan; Lee, Jeffrey K; Schneider, Jennifer L; Chang-Claude, Jenny; Kim, Jeongseon; Huyghe, Jeroen R; Zheng, Jiayin.
Affiliation
  • Thomas M; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
  • Su YR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
  • Rosenthal EA; Biostatistics Division, Kaiser Permanente Washington Health Research Institute, Seattle, USA.
  • Sakoda LC; Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, 98195, USA.
  • Schmit SL; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
  • Timofeeva MN; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
  • Chen Z; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Fernandez-Rozadilla C; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, USA.
  • Law PJ; Danish Institute for Advanced Study (DIAS), Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Murphy N; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, U, Germany.
  • Carreras-Torres R; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Diez-Obrero V; Instituto de Investigacion Sanitaria de Santiago (IDIS), Choupana sn, 15706, Santiago de Compostela, Spain.
  • van Duijnhoven FJB; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Jiang S; Division of Genetics and Epidemiology, The Institute of Cancer Reseach, London, SW7 3RP, UK.
  • Shin A; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Wolk A; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, 17190, Girona, Spain.
  • Phipps AI; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, 08908, Spain.
  • Burnett-Hartman A; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, 08908, Spain.
  • Gsur A; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, 08908, Spain.
  • Chan AT; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
  • Zauber AG; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
  • Wu AH; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, South Korea.
  • Lindblom A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Um CY; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
  • Tangen CM; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Gignoux C; Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA.
  • Newton C; .Center for Cancer Research, Medical University Vienna, Vienna, Austria.
  • Haiman CA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Qu C; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Bishop DT; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Buchanan DD; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Crosslin DR; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Conti DV; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Kim DH; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Hauser E; University of Southern California, Preventative Medicine, Los Angeles, CA, USA.
  • White E; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
  • Siegel E; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
  • Schumacher FR; Department of Population Science, American Cancer Society, Atlanta, GA, USA.
  • Rennert G; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Giles GG; Colorado Center for Personalized Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
  • Hampel H; Department of Population Science, American Cancer Society, Atlanta, GA, USA.
  • Brenner H; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Oze I; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
  • Oh JH; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
  • Lee JK; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Schneider JL; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3000, Australia.
  • Chang-Claude J; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, VIC, 3000, Australia.
  • Kim J; Department of Bioinformatics and Medical Education, University of Washington Medical Center, Seattle, WA, 98195, USA.
  • Huyghe JR; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Zheng J; Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea.
Nat Commun ; 14(1): 6147, 2023 10 02.
Article in En | MEDLINE | ID: mdl-37783704
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Ethnicity Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Ethnicity Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom