Significant cell uptake of Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector.

Hall, Andrew J; Robertson, Amy G; Baker, Robert W; Hill, Leila R; Rendina, Louis M

Hall, Andrew J; Robertson, Amy G; Baker, Robert W; Hill, Leila R; Rendina, Louis M.

Affiliation

Hall AJ; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. louis.rendina@sydney.edu.au.
Robertson AG; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. louis.rendina@sydney.edu.au.
Baker RW; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. louis.rendina@sydney.edu.au.
Hill LR; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. louis.rendina@sydney.edu.au.
Rendina LM; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. louis.rendina@sydney.edu.au.

Chem Commun (Camb) ; 59(83): 12511-12514, 2023 Oct 17.

Article in En | MEDLINE | ID: mdl-37789720

ABSTRACT

ABSTRACT

The synthesis, characterisation, and tumour cell uptake of six novel Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes are reported. The propyl-linked Gd(III) complexes can accumulate inside human glioma cells at prodigious levels, approaching 1200%, over the parent triphenylphosphonium salts. DFT and quantum chemical topology analyses support a new type of conformationally-dependent tumour cell targeting vector.

Subject(s)

Gadolinium; Neoplasms; Humans; Gadolinium/pharmacology; Gadolinium/chemistry; Neoplasms/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gadolinium / Neoplasms Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Australia

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