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Palmitoylation of the hemagglutinin of influenza B virus by ER-localized DHHC enzymes 1, 2, 4, and 6 is required for efficient virus replication.
Meng, Xiaorong; Veit, Michael.
Affiliation
  • Meng X; Veterinary Faculty, Institute for Virology, Freie Universität Berlin , Berlin, Germany.
  • Veit M; Veterinary Faculty, Institute for Virology, Freie Universität Berlin , Berlin, Germany.
J Virol ; 97(10): e0124523, 2023 10 31.
Article in En | MEDLINE | ID: mdl-37792001
IMPORTANCE: Influenza viruses are a public health concern since they cause seasonal outbreaks and occasionally pandemics. Our study investigates the importance of a protein modification called "palmitoylation" in the replication of influenza B virus. Palmitoylation involves attaching fatty acids to the viral protein hemagglutinin and has previously been studied for influenza A virus. We found that this modification is important for the influenza B virus to replicate, as mutating the sites where palmitate is attached prevented the virus from generating viable particles. Our experiments also showed that this modification occurs in the endoplasmic reticulum. We identified the specific enzymes responsible for this modification, which are different from those involved in palmitoylation of HA of influenza A virus. Overall, our research illuminates the similarities and differences in fatty acid attachment to HA of influenza A and B viruses and identifies the responsible enzymes, which might be promising targets for anti-viral therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza B virus / Virus Replication / Acyltransferases / Palmitic Acid / Hemagglutinin Glycoproteins, Influenza Virus / Endoplasmic Reticulum / Lipoylation Limits: Humans Language: En Journal: J Virol Year: 2023 Document type: Article Affiliation country: Germany Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza B virus / Virus Replication / Acyltransferases / Palmitic Acid / Hemagglutinin Glycoproteins, Influenza Virus / Endoplasmic Reticulum / Lipoylation Limits: Humans Language: En Journal: J Virol Year: 2023 Document type: Article Affiliation country: Germany Country of publication: United States