Advances in Cardiac Organoids.
Front Biosci (Landmark Ed)
; 28(9): 221, 2023 09 25.
Article
in En
| MEDLINE
| ID: mdl-37796702
ABSTRACT
Cardiovascular diseases rank as the leading cause of death worldwide and are a major contributor to disability, posing a significant threat to human health. Organoids offer a partial simulation of the structure and function of the tissue of origin. It is a promising model that can supplement the disadvantages of two-dimensional culture and animal models. Due to the complexity of heart development, the research of cardiac organoids is still maturing. The advancement of technology has helped address certain challenges, but it has also unveiled new issues and complexities. This paper summarizes the application of organoids technology in the cardiovascular field, the common construction methods of cardiac organoids, and the latest progress of cardiac organoids in the fields of disease model construction, cardiac development research, drug research, and regenerative medicine. The future development and challenges of cardiac organoids are also addressed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organoids
/
Heart
Limits:
Animals
/
Humans
Language:
En
Journal:
Front Biosci (Landmark Ed)
Year:
2023
Document type:
Article
Affiliation country:
China