Targeting KRAS for the potential treatment of pancreatic ductal adenocarcinoma: Recent advancements provide hope (Review).

Zhang, Joshua; Darman, Lily; Hassan, Md Sazzad; Von Holzen, Urs; Awasthi, Niranjan

Zhang, Joshua; Darman, Lily; Hassan, Md Sazzad; Von Holzen, Urs; Awasthi, Niranjan.

Affiliation

Zhang J; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Darman L; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Hassan MS; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556, USA.
Von Holzen U; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556, USA.
Awasthi N; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556, USA.

Oncol Rep ; 50(5)2023 Nov.

Article in En | MEDLINE | ID: mdl-37800636

Subject(s)

Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Lung Neoplasms; Pancreatic Neoplasms; Humans; Proto-Oncogene Proteins p21(ras)/genetics; Proto-Oncogene Proteins p21(ras)/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Pancreatic Neoplasms/drug therapy; Pancreatic Neoplasms/genetics; Pancreatic Neoplasms/metabolism; Carcinoma, Pancreatic Ductal/drug therapy; Carcinoma, Pancreatic Ductal/genetics; Carcinoma, Pancreatic Ductal/metabolism; Mutation; Pancreatic Neoplasms

Key words

KRAS; MAPK; PDAC; PI3K; pancreatic cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Non-Small-Cell Lung / Carcinoma, Pancreatic Ductal / Lung Neoplasms Limits: Humans Language: En Journal: Oncol Rep Journal subject: NEOPLASIAS Year: 2023 Document type: Article Affiliation country: United States Country of publication: Greece

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