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Characteristic and health risk of per- and polyfluoroalkyl substances from cosmetics via dermal exposure.
Lin, Xia; Xing, Yudong; Chen, Huijun; Zhou, Yan; Zhang, Xin; Liu, Peng; Li, Jiaoyang; Lee, Hian Kee; Huang, Zhenzhen.
Affiliation
  • Lin X; Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, 430071, PR China.
  • Xing Y; Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, 430071, PR China.
  • Chen H; Department of Gynecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China.
  • Zhou Y; Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, 430071, PR China.
  • Zhang X; Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, 430071, PR China.
  • Liu P; Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, 430071, PR China.
  • Li J; Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, 430071, PR China.
  • Lee HK; Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
  • Huang Z; Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, 430071, PR China. Electronic address: zzhuang@whu.edu.cn.
Environ Pollut ; 338: 122685, 2023 Dec 01.
Article in En | MEDLINE | ID: mdl-37804905
ABSTRACT
In this work, 45 cosmetic samples were collected from China, and 27 target per- and polyfluoroalkyl substances (PFAS) were analyzed by ultrahigh-performance liquid chromatography-high resolution mass spectrometry. PFAS were found in all samples, including the products marketed for pregnant women, and the total concentrations of PFAS measured in each sample were in the range of 4.05 - 94.9 ng/g. Short-chain perfluorinated carboxylic acids were the dominant compounds contributing to over 60% of the total content. Perfluorobutanoic acid, with high placental transfer efficiency, was the major PFAS in cosmetics for pregnant women. Three emerging PFAS, 2-perfluorohexyl ethanoic acid, 3-perfluoropentyl propanoic acid (53) and perfluoro-2-propoxypropanoic acid, were also identified in the cosmetic samples at quantifiable levels. Significantly, positive correlations between individual PFAS were observed, indicating that there may be a common source for PFAS in these samples. Statistical analyses suggested that using plastic containers and precursor substances may be potential sources of PFAS in terminal products, and product aging may increase PFAS levels. From the PFAS analysis of the cosmetics, the margin of safety (MoS) and hazard quotient (HQ) were calculated to assess human health risks through dermal exposure by using these products. Although the MoS and HQ values obtained were deemed acceptable, the cumulative effect caused by composite and long-term exposure to these contaminants needs to be given greater attention by health authorities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkanesulfonic Acids / Fluorocarbons Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Pregnancy Country/Region as subject: Asia Language: En Journal: Environ Pollut Journal subject: SAUDE AMBIENTAL Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkanesulfonic Acids / Fluorocarbons Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Pregnancy Country/Region as subject: Asia Language: En Journal: Environ Pollut Journal subject: SAUDE AMBIENTAL Year: 2023 Document type: Article