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Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera.
Mühlemann, Barbara; Wilks, Samuel H; Baracco, Lauren; Bekliz, Meriem; Carreño, Juan Manuel; Corman, Victor M; Davis-Gardner, Meredith E; Dejnirattisai, Wanwisa; Diamond, Michael S; Douek, Daniel C; Drosten, Christian; Eckerle, Isabella; Edara, Venkata-Viswanadh; Ellis, Madison; Fouchier, Ron A M; Frieman, Matthew; Godbole, Sucheta; Haagmans, Bart; Halfmann, Peter J; Henry, Amy R; Jones, Terry C; Katzelnick, Leah C; Kawaoka, Yoshihiro; Kimpel, Janine; Krammer, Florian; Lai, Lilin; Liu, Chang; Lusvarghi, Sabrina; Meyer, Benjamin; Mongkolsapaya, Juthathip; Montefiori, David C; Mykytyn, Anna; Netzl, Antonia; Pollett, Simon; Rössler, Annika; Screaton, Gavin R; Shen, Xiaoying; Sigal, Alex; Simon, Viviana; Subramanian, Rahul; Supasa, Piyada; Suthar, Mehul; Türeli, Sina; Wang, Wei; Weiss, Carol D; Smith, Derek J.
Affiliation
  • Mühlemann B; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Wilks SH; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
  • Baracco L; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
  • Bekliz M; Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Carreño JM; Department of Medicine, Faculty of Medicine, University of Geneva, Switzerland.
  • Corman VM; Centre for Emerging Viral Diseases, University Hospitals of Geneva and University of Geneva, Switzerland.
  • Davis-Gardner ME; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Dejnirattisai W; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Diamond MS; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
  • Douek DC; Department of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
  • Drosten C; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
  • Eckerle I; Division of Emerging Infectious Disease, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand.
  • Edara VV; Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Ellis M; Andrew M. and Jane M. Bursky the Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.
  • Fouchier RAM; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA.
  • Frieman M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Godbole S; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Haagmans B; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
  • Halfmann PJ; Department of Medicine, Faculty of Medicine, University of Geneva, Switzerland.
  • Henry AR; Centre for Emerging Viral Diseases, University Hospitals of Geneva and University of Geneva, Switzerland.
  • Jones TC; Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland.
  • Katzelnick LC; Department of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
  • Kawaoka Y; Department of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
  • Kimpel J; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • Krammer F; Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Lai L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Liu C; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • Lusvarghi S; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • Meyer B; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Mongkolsapaya J; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Montefiori DC; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
  • Mykytyn A; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
  • Netzl A; Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Pollett S; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • Rössler A; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
  • Screaton GR; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo 162-8655, Japan.
  • Shen X; Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Tokyo 162-8655, Japan.
  • Sigal A; Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck, Peter-Mayr-Str. 4b, 6020 Innsbruck, Austria.
  • Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Subramanian R; Department of Pathology, Cellular and Molecular Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Supasa P; Department of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
  • Suthar M; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
  • Türeli S; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
  • Wang W; Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20903, USA.
  • Weiss CD; Centre of Vaccinology, Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
  • Smith DJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
bioRxiv ; 2023 Sep 27.
Article in En | MEDLINE | ID: mdl-37808679
The antigenic evolution of SARS-CoV-2 requires ongoing monitoring to judge the immune escape of newly arising variants. A surveillance system necessitates an understanding of differences in neutralization titers measured in different assays and using human and animal sera. We compared 18 datasets generated using human, hamster, and mouse sera, and six different neutralization assays. Titer magnitude was lowest in human, intermediate in hamster, and highest in mouse sera. Fold change, immunodominance patterns and antigenic maps were similar among sera. Most assays yielded similar results, except for differences in fold change in cytopathic effect assays. Not enough data was available for conclusively judging mouse sera, but hamster sera were a consistent surrogate for human first-infection sera.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2023 Document type: Article Affiliation country: Germany Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2023 Document type: Article Affiliation country: Germany Country of publication: United States