Direct alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis.
Chem Commun (Camb)
; 59(85): 12763-12766, 2023 Oct 24.
Article
in En
| MEDLINE
| ID: mdl-37812023
ABSTRACT
The metal-free alkylation of N-heterocycles with alkenes has remained a synthetic challenge. We report here the successful implementation of metal-free alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis. This protocol provides a mechanistically distinct approach to prepare a variety of C-3 alkylated quinoxalinones that are otherwise quite difficult to synthesize by other means.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2023
Document type:
Article
Affiliation country:
China
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM