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Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis.
Larson, Erica C; Ellis-Connell, Amy L; Rodgers, Mark A; Gubernat, Abigail K; Gleim, Janelle L; Moriarty, Ryan V; Balgeman, Alexis J; Ameel, Cassaundra L; Jauro, Solomon; Tomko, Jaime A; Kracinovsky, Kara B; Maiello, Pauline; Borish, H Jake; White, Alexander G; Klein, Edwin; Bucsan, Allison N; Darrah, Patricia A; Seder, Robert A; Roederer, Mario; Lin, Philana Ling; Flynn, JoAnne L; O'Connor, Shelby L; Scanga, Charles A.
Affiliation
  • Larson EC; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. erl72@pitt.edu.
  • Ellis-Connell AL; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. erl72@pitt.edu.
  • Rodgers MA; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA.
  • Gubernat AK; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Gleim JL; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Moriarty RV; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Balgeman AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA.
  • Ameel CL; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA.
  • Jauro S; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Tomko JA; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Kracinovsky KB; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Maiello P; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Borish HJ; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • White AG; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Klein E; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Bucsan AN; Division of Laboratory Animal Resources, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Darrah PA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Seder RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Lin PL; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Flynn JL; Department of Pediatrics, Children's Hospital of Pittsburgh, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • O'Connor SL; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Scanga CA; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nat Microbiol ; 8(11): 2080-2092, 2023 Nov.
Article in En | MEDLINE | ID: mdl-37814073
ABSTRACT
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille Calmette-Guérin (BCG) delivery is the only licensed vaccine against tuberculosis; however, it offers little protection from pulmonary tuberculosis in adults and is contraindicated in people living with HIV. Intravenous BCG confers protection against Mtb infection in rhesus macaques; we hypothesized that it might prevent tuberculosis in simian immunodeficiency virus (SIV)-infected macaques, a model for HIV infection. Here intravenous BCG-elicited robust airway T cell influx and elevated plasma and airway antibody titres in both SIV-infected and naive animals. Following Mtb challenge, all 7 vaccinated SIV-naive and 9 out of 12 vaccinated SIV-infected animals were protected, without any culturable bacteria detected from tissues. Peripheral blood mononuclear cell responses post-challenge indicated early clearance of Mtb in vaccinated animals, regardless of SIV infection. These data support that intravenous BCG is immunogenic and efficacious in SIV-infected animals.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / HIV Infections / Simian Acquired Immunodeficiency Syndrome / Simian Immunodeficiency Virus Limits: Animals / Humans Language: En Journal: Nat Microbiol Year: 2023 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / HIV Infections / Simian Acquired Immunodeficiency Syndrome / Simian Immunodeficiency Virus Limits: Animals / Humans Language: En Journal: Nat Microbiol Year: 2023 Document type: Article Affiliation country: United States