High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints.

Jansen, Anouk M E; Ter Heine, Rob; Verweij, Paul E; Brüggemann, Roger J M

Jansen, Anouk M E; Ter Heine, Rob; Verweij, Paul E; Brüggemann, Roger J M.

Affiliation

Jansen AME; Department of Pharmacy, Radboud university Medical Center, Radboud Institute for Medical Innovations, Geert Grooteplein-Zuid 10, Postbox 9101, 6500 HB, Nijmegen, The Netherlands. anouk.me.jansen@radboudumc.nl.
Ter Heine R; Radboud University Medical Center-Canisius Wilhelmina Ziekenhuis Center of Expertise for Mycology, Nijmegen, The Netherlands. anouk.me.jansen@radboudumc.nl.
Verweij PE; Department of Pharmacy, Radboud university Medical Center, Radboud Institute for Medical Innovations, Geert Grooteplein-Zuid 10, Postbox 9101, 6500 HB, Nijmegen, The Netherlands.
Brüggemann RJM; Radboud University Medical Center-Canisius Wilhelmina Ziekenhuis Center of Expertise for Mycology, Nijmegen, The Netherlands.

Clin Pharmacokinet ; 62(12): 1695-1699, 2023 12.

Article in En | MEDLINE | ID: mdl-37819504

ABSTRACT

ABSTRACT

Isavuconazole exposure-response relationships have been studied with a focus on total rather than unbound exposure, assuming a constant unbound fraction of 1%. We observed a median (range) unbound fraction of 1.59% (0.42-5.30%) in patients. This highly variable protein binding asks for re-evaluation of current pharmacokinetic and pharmacodynamic targets for isavuconazole.

Subject(s)

Nitriles; Pyridines; Humans; Protein Binding; Nitriles/pharmacokinetics; Pyridines/therapeutic use; Pyridines/pharmacokinetics; Triazoles/pharmacokinetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Nitriles Limits: Humans Language: En Journal: Clin Pharmacokinet Year: 2023 Document type: Article Affiliation country: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google