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Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross-priming.
Luri-Rey, Carlos; Gomis, Gabriel; Glez-Vaz, Javier; Manzanal, Almudena; Martinez Riaño, Ana; Rodriguez Ruiz, Maria E; Teijeira, Alvaro; Melero, Ignacio.
Affiliation
  • Luri-Rey C; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
  • Gomis G; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
  • Glez-Vaz J; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
  • Manzanal A; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
  • Martinez Riaño A; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
  • Rodriguez Ruiz ME; Department of Oncology, Clinica Universidad de Navarra, Pamplona, Spain.
  • Teijeira A; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
  • Melero I; Department of Oncology, Clinica Universidad de Navarra, Pamplona, Spain.
Immunol Rev ; 321(1): 143-151, 2024 Jan.
Article in En | MEDLINE | ID: mdl-37822051
ABSTRACT
Antigen cross-priming of CD8+ T cells is a critical process necessary for the effective expansion and activation of CD8+ T cells endowed with the ability to recognize and destroy tumor cells. The cross-presentation of tumor antigens to cross-prime CD8+ T cells is mainly mediated, if not only, by a subset of professional antigen-presenting cells termed type-1 conventional dendritic cells (cDC1). The demise of malignant cells can be immunogenic if it occurs in the context of premortem stress. These ways of dying are termed immunogenic cell death (ICD) and are associated with biochemical features favoring cDC1 for the efficient cross-priming of tumor antigens. Immunosurveillance and the success of immunotherapies heavily rely on the ability of cytotoxic immune cells, primarily CD8+ T cells and NK cells, to detect and eliminate tumor cells through mechanisms collectively known as cytotoxicity. Recent studies have revealed the significance of NK- and CTL-mediated cytotoxicity as a prominent form of immunogenic cell death, resulting in mechanisms that promote and sustain antigen-specific immune responses. This review focuses on the mechanisms underlying the cross-presentation of antigens released during tumor cell killing by cytotoxic immune cells, with an emphasis on the role of cDC1 cells. Indeed, cDC1s are instrumental in the effectiveness of most immunotherapies, underscoring the significance of tumor antigen cross-priming in contexts of immunogenic cell death. The notion of the potent immunogenicity of cell death resulting from NK or cytotoxic T lymphocyte (CTL)-mediated cytotoxicity has far-reaching implications for cancer immunotherapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Cross-Priming Limits: Humans Language: En Journal: Immunol Rev Year: 2024 Document type: Article Affiliation country: Spain

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Cross-Priming Limits: Humans Language: En Journal: Immunol Rev Year: 2024 Document type: Article Affiliation country: Spain
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