Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection.
J Infect Dis
; 228(9): 1292-1298, 2023 11 02.
Article
in En
| MEDLINE
| ID: mdl-37832036
ABSTRACT
Cryptosporidium species are a major cause of diarrhea and associated with growth failure. There is currently only limited knowledge of the parasite's genomic variability. We report a genomic analysis of Cryptosporidium parvum isolated from Bangladeshi infants and reanalysis of sequences from the United Kingdom. Human isolates from both locations shared 154 variants not present in the cattle-derived reference genome, suggesting host-specific adaptation of the parasite. Remarkably 34.6% of single-nucleotide polymorphisms unique to human isolates were nonsynonymous and 8.2% of these were in secreted proteins. Linkage disequilibrium decay indicated frequent recombination. The genetic diversity of C. parvum has potential implications for vaccine and therapeutic design. Clinical Trials Registration. NCT02764918.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parasites
/
Cryptosporidium parvum
/
Cryptosporidiosis
/
Cryptosporidium
Limits:
Animals
/
Child
/
Humans
/
Infant
Country/Region as subject:
Asia
Language:
En
Journal:
J Infect Dis
Year:
2023
Document type:
Article
Affiliation country:
United States