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Pediatric Hepatocellular Adenomas: What Is Known and What Is New?
Espinoza, Andres F; Vasudevan, Sanjeev A; Masand, Prakash M; Lòpez-Terrada, Dolores H; Patel, Kalyani R.
Affiliation
  • Espinoza AF; Divisions of Pediatric Surgery and Surgical Research, Michael E. DeBakey Department of Surgery, Pediatric Surgical Oncology Laboratory, Texas Children's Surgical Oncology Program, Texas Children's Liver Tumor Program, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Vasudevan SA; Divisions of Pediatric Surgery and Surgical Research, Michael E. DeBakey Department of Surgery, Pediatric Surgical Oncology Laboratory, Texas Children's Surgical Oncology Program, Texas Children's Liver Tumor Program, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Masand PM; Department of Radiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA.
  • Lòpez-Terrada DH; Department of Pathology and Immunology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA.
  • Patel KR; Department of Pathology and Immunology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA.
Cancers (Basel) ; 15(19)2023 Sep 29.
Article in En | MEDLINE | ID: mdl-37835484
Current understanding and classification of pediatric hepatocellular adenomas (HCA) are largely based on adult data. HCAs are rare in children and, unlike in adults, are often seen in the context of syndromes or abnormal background liver. Attempts to apply the adult classification to pediatric tumors have led to several "unclassifiable" lesions. Although typically considered benign, few can show atypical features and those with beta-catenin mutations have a risk for malignant transformation. Small lesions can be monitored while larger (>5.0 cm) lesions are excised due to symptoms or risk of bleeding/rupture, etc. Management depends on gender, age, underlying liver disease, multifocality, size of lesion, histologic subtype and presence of mutation, if any. In this review, we summarize the data on pediatric HCAs and highlight our experience with their diagnosis and management.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancers (Basel) Year: 2023 Document type: Article Affiliation country: United States Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancers (Basel) Year: 2023 Document type: Article Affiliation country: United States Country of publication: Switzerland