Gold@mesoporous polydopamine nanoparticles modified self-healing hydrogel for sport-injuring therapy.

ABSTRACT

Sports-related damage is a prevalent issue, which a combination therapy including photothermal irradiation, self-healing dressing and antibacterial treatment is an effective way to rehabilitate it. In the study, a multifunctional hydrogel was developed to meet the requirement. Firstly, mesoporous polydopamine (MPDA) was prepared, where gold nanoparticles (Au NPs) were formed in its mesoporous structure, to construct Au@MPDA NPs with nanosize about 200 nm. Synergetic and efficient photothermal effect was achieved by the combination of the two photothermal agents. The Au@MPDA NPs were then added to modify polyvinyl alcohol-carboxymethyl chitosan-borax (PCB) hydrogel. Via rheological property characterization, cell experiments and antibacterial evaluation, high photothermal efficiency and effective antibacterial activity of Au@MPDA@PCB hydrogel was obtained with the aid of Au@MPDA NPs, together with self-healing property. When treated in motion-related tissue, the modified hydrogel showed excellent adaptive property and photothermal effect in situ. This study is beneficial for developing a novel rehabilitation treatment strategy for sports-related injuries.