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Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis.
Rady, Amgad M; El-Sayed, Ashraf S A; El-Baz, Ashraf F; Abdel-Fattah, Ghada G; Magdeldin, Sameh; Ahmed, Eman; Osama, Aya; Hassanein, Sameh E; Saed, Hend; Yassin, Marwa.
Affiliation
  • Rady AM; Enzymology and Fungal Biotechnology Lab (EFBL), Botany and Microbiology Department, Faculty of Science, Zagazig University , Zagazig, Egypt.
  • El-Sayed ASA; Faculty of Biotechnology, October University for Modern Sciences and Arts , Giza, Egypt.
  • El-Baz AF; Enzymology and Fungal Biotechnology Lab (EFBL), Botany and Microbiology Department, Faculty of Science, Zagazig University , Zagazig, Egypt.
  • Abdel-Fattah GG; Genetic Engineering and Biotechnology Research Institute, University of Sadat City , Sadat City, Egypt.
  • Magdeldin S; Botany Department, Faculty of Science, Mansoura University , Mansoura, Egypt.
  • Ahmed E; Proteomics and Metabolomics Research Program, Department of Basic Research, Children's Cancer Hospital , Cairo, Egypt.
  • Osama A; Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University , Ismailia, Egypt.
  • Hassanein SE; Proteomics and Metabolomics Research Program, Department of Basic Research, Children's Cancer Hospital , Cairo, Egypt.
  • Saed H; Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University , Ismailia, Egypt.
  • Yassin M; Proteomics and Metabolomics Research Program, Department of Basic Research, Children's Cancer Hospital , Cairo, Egypt.
Microbiol Spectr ; 11(6): e0228123, 2023 Dec 12.
Article in En | MEDLINE | ID: mdl-37855596
IMPORTANCE: Decreasing the camptothecin productivity by fungi with storage and subculturing is the challenge that halts their further implementation to be an industrial platform for camptothecin (CPT) production. The highest differentially abundant proteins were Pleckstrin homology (PH) domain-containing proteins and Peptidyl-prolyl cis/trans isomerase that fluctuated with the subculturing of A. terreus with a remarkable relation to CPT biosynthesis and restored with addition of F. elastica microbiome.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteomics / Pleckstrin Homology Domains Language: En Journal: Microbiol Spectr Year: 2023 Document type: Article Affiliation country: Egypt Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteomics / Pleckstrin Homology Domains Language: En Journal: Microbiol Spectr Year: 2023 Document type: Article Affiliation country: Egypt Country of publication: United States