Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics.

Kumari, Nitu; Antil, Himanshu; Kumari, Susmita; Raghavan, Sathees C

Kumari, Nitu; Antil, Himanshu; Kumari, Susmita; Raghavan, Sathees C.

Affiliation

Kumari N; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Antil H; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Kumari S; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Raghavan SC; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India. Electronic address: sathees@iisc.ac.in.

Genomics ; 115(6): 110731, 2023 Nov.

Article in En | MEDLINE | ID: mdl-37871849

Subject(s)

DNA Ligase ATP; Uterine Cervical Neoplasms; Animals; Female; Humans; Mice; DNA Damage/genetics; DNA End-Joining Repair; DNA Ligase ATP/genetics; DNA Ligase ATP/metabolism; DNA Ligases/genetics; DNA Ligases/metabolism; DNA Repair/genetics; Ligases/genetics; Ligases/metabolism; Uterine Cervical Neoplasms/genetics; Uterine Cervical Neoplasms/metabolism

Key words

Cancer therapy; DNA repair; Double-strand breaks; MMEJ; Microhomology mediated end joining; NHEJ; Nonhomologous DNA end joining

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / DNA Ligase ATP Limits: Animals / Female / Humans Language: En Journal: Genomics Journal subject: GENETICA Year: 2023 Document type: Article Affiliation country: India Country of publication: United States

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