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Local recurrence and metachronous multiple cancers after transoral nonrobotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study.
Ushiro, Koji; Watanabe, Yoshiki; Kishimoto, Yo; Kawai, Yoshitaka; Fujimura, Shintaro; Asato, Ryo; Tsujimura, Takashi; Hori, Ryusuke; Kumabe, Yohei; Yasuda, Kaori; Tamaki, Hisanobu; Iki, Takehiro; Kitani, Yoshiharu; Kurata, Keisuke; Kojima, Tsuyoshi; Takata, Kuniaki; Kada, Shinpei; Takebayashi, Shinji; Shinohara, Shogo; Hamaguchi, Kiyomi; Miyazaki, Masakazu; Ikenaga, Tadashi; Maetani, Toshiki; Harada, Hiroyuki; Haji, Tomoyuki; Omori, Koichi.
Affiliation
  • Ushiro K; Department of Otolaryngology - Head & Neck Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
  • Watanabe Y; Department of Otolaryngology - Head & Neck Surgery, Japanese Red Cross Osaka Hospital, Osaka, Japan.
  • Kishimoto Y; Department of Otolaryngology - Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kawai Y; Department of Otolaryngology - Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Fujimura S; Department of Otolaryngology - Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Asato R; Department of Otolaryngology - Head & Neck Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
  • Tsujimura T; Department of Otolaryngology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
  • Hori R; Department of Otolaryngology - Head and Neck Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Kumabe Y; Department of Otolaryngology - Head & Neck Surgery, Fujita Health University, Toyoake, Japan.
  • Yasuda K; Department of Otolaryngology - Head & Neck Surgery, Tenri Hospital, Tenri, Japan.
  • Tamaki H; Department of Otolaryngology - Head & Neck Surgery, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
  • Iki T; Department of Otolaryngology - Head & Neck Surgery, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
  • Kitani Y; Department of Otolaryngology - Head & Neck Surgery, Kurashiki Central Hospital, Kurashiki, Japan.
  • Kurata K; Department of Otolaryngology - Head & Neck Surgery, Kurashiki Central Hospital, Kurashiki, Japan.
  • Kojima T; Department of Otolaryngology - Head & Neck Surgery, Shizuoka General Hospital, Shizuoka, Japan.
  • Takata K; Department of Otolaryngology - Head & Neck Surgery, Shizuoka General Hospital, Shizuoka, Japan.
  • Kada S; Department of Otolaryngology - Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Takebayashi S; Department of Otolaryngology - Head & Neck Surgery, Tenri Hospital, Tenri, Japan.
  • Shinohara S; Department of Otolaryngology - Head & Neck Surgery, Tenri Hospital, Tenri, Japan.
  • Hamaguchi K; Department of Otolaryngology - Head & Neck Surgery, Japanese Red Cross Otsu Hospital, Otsu, Japan.
  • Miyazaki M; Department of Otolaryngology - Head & Neck Surgery, Shiga General Hospital, Moriyama, Japan.
  • Ikenaga T; Department of Otolaryngology - Head & Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Maetani T; Department of Otolaryngology - Head & Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Harada H; Department of Otolaryngology - Head & Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Haji T; Department of Otolaryngology - Head & Neck Surgery, Nara Prefecture General Medical Center, Nara, Japan.
  • Omori K; Department of Otolaryngology - Head & Neck Surgery, Nara Prefecture General Medical Center, Nara, Japan.
Head Neck ; 46(1): 118-128, 2024 Jan.
Article in En | MEDLINE | ID: mdl-37897205
ABSTRACT

BACKGROUND:

Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers.

METHODS:

We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in patients who underwent transoral nonrobotic surgery for laryngopharyngeal squamous cell carcinoma without lymph node metastases between 2015 and 2021 in a multicenter retrospective study.

RESULTS:

Four hundred and fifty-seven patients were included. Positive surgical margins were found in 121 patients (26.5%). Twenty-two patients (4.8%) received additional treatment. Positive horizontal margins of invasive carcinoma (p = 0.003) and positive horizontal margins of carcinoma in situ only (p = 0.032) were independent risk factors for local recurrence, and prior radiotherapy (p = 0.001) for metachronous multiple cancers. Local control was significantly worse without additional treatment (p = 0.049), but there was no significant difference in survival.

CONCLUSIONS:

Patients with positive margins had an increased frequency of local recurrence, but salvage therapy was effective.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Hypopharyngeal Neoplasms / Head and Neck Neoplasms Limits: Humans Language: En Journal: Head Neck Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Japan
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Hypopharyngeal Neoplasms / Head and Neck Neoplasms Limits: Humans Language: En Journal: Head Neck Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Japan