Local recurrence and metachronous multiple cancers after transoral nonrobotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study.
Head Neck
; 46(1): 118-128, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-37897205
ABSTRACT
BACKGROUND:
Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers.METHODS:
We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in patients who underwent transoral nonrobotic surgery for laryngopharyngeal squamous cell carcinoma without lymph node metastases between 2015 and 2021 in a multicenter retrospective study.RESULTS:
Four hundred and fifty-seven patients were included. Positive surgical margins were found in 121 patients (26.5%). Twenty-two patients (4.8%) received additional treatment. Positive horizontal margins of invasive carcinoma (p = 0.003) and positive horizontal margins of carcinoma in situ only (p = 0.032) were independent risk factors for local recurrence, and prior radiotherapy (p = 0.001) for metachronous multiple cancers. Local control was significantly worse without additional treatment (p = 0.049), but there was no significant difference in survival.CONCLUSIONS:
Patients with positive margins had an increased frequency of local recurrence, but salvage therapy was effective.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Hypopharyngeal Neoplasms
/
Head and Neck Neoplasms
Limits:
Humans
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country:
Japan