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Four new alkaloids from the roots of Dactylicapnos scandens.
Wu, Qian; Hu, Ruo-Xi; Han, Yan-Ru; Zhu, Qian; Zhang, Wan-Jin; Chen, Juan; Zhang, Fan; Zhang, Chun-Lei; Cao, Zheng-Yu.
Affiliation
  • Wu Q; Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
  • Hu RX; Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
  • Han YR; Henan Privince Hospital of Traditional Chinese Medicine, Zhengzhou 450053, China.
  • Zhu Q; Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
  • Zhang WJ; Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
  • Chen J; Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
  • Zhang F; Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
  • Zhang CL; Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
  • Cao ZY; Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
J Asian Nat Prod Res ; 26(2): 248-258, 2024 Feb.
Article in En | MEDLINE | ID: mdl-37905564
ABSTRACT
Four new alkaloids (1 - 4), together with five known ones (5 - 9), were isolated from the bulbs of Dactylicapnos scandens. The structures were determined by analysis of their spectroscopic data and quantum-chemical calculations. All the isolates were tested for their ability to modulate neuronal Ca2+ mobilization in primary cultured neocortical neurons. Compound 8 inhibited spontaneous Ca2+ oscillations at low micromolar concentrations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkaloids Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkaloids Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Document type: Article Affiliation country: China