Characterization of reaction products between styrene oxide and deoxynucleosides and DNA.
Chem Biol Interact
; 60(3): 235-46, 1986 Dec.
Article
in En
| MEDLINE
| ID: mdl-3791490
ABSTRACT
Styrene oxide was reacted with deoxynucleosides and DNA in aqueous buffer at pH 7.4. The products were purified by HPLC, characterized by UV spectroscopy and by chemical ionization mass spectrometry. The main products identified were 7-alkyl-, N2-alkyl- and O6-alkyldeoxyguanosine, 1-alkyl-, and N6-alkyldeoxyadenosine, N4-alkyl-, 3-alkyl- and O2-alkyldeoxycytidine and 3-alkylthymidine. The relative yields of alkylated deoxynucleosides were dG greater than dC greater than dA greater than T. In the reactions of styrene oxide with DNA the dominant product isolated was 7-alkylguanine but N2-alkylguanine was also detected.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
/
Deoxyribonucleosides
/
Epoxy Compounds
/
Ethers, Cyclic
Limits:
Animals
Language:
En
Journal:
Chem Biol Interact
Year:
1986
Document type:
Article
Publication country:
IE
/
IRELAND
/
IRLANDA