A deconstruction-reconstruction strategy to access 1-naphthol derivatives: application to the synthesis of aristolactam scaffolds.
Org Biomol Chem
; 21(44): 8936-8941, 2023 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-37916683
A deconstruction-reconstruction strategy for the synthesis of multisubstituted polycyclic aromatic hydrocarbons (PAHs) is delineated herein. The deconstruction step enables the synthesis of o-cyanomethylaroyl fluorides that are bifunctional substrates holding both a pro-nucleophile and an electrophile. The construction step involves a formal [4 + 2] benzannulation using o-cyanomethylaroyl fluorides and active methylenes. The utility of this synthetic method is also demonstrated by the synthesis of a tetracyclic aristolactam derivative.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2023
Document type:
Article
Country of publication:
United kingdom