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Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates.
Stanikova, Andrea; Jouza, Martin; Bohosova, Julia; Slaby, Ondrej; Jabandziev, Petr.
Affiliation
  • Stanikova A; Department of Neonatology, University Hospital Brno, Brno, Czech Republic.
  • Jouza M; Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Bohosova J; Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Slaby O; Department of Pediatrics, University Hospital Brno, Brno, Czech Republic.
  • Jabandziev P; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
BMJ Paediatr Open ; 7(1)2023 11.
Article in En | MEDLINE | ID: mdl-37918941
ABSTRACT
Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC's pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enterocolitis, Necrotizing / Gastrointestinal Microbiome / Infant, Newborn, Diseases Limits: Humans / Newborn Language: En Journal: BMJ Paediatr Open Year: 2023 Document type: Article Affiliation country: Czech Republic

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enterocolitis, Necrotizing / Gastrointestinal Microbiome / Infant, Newborn, Diseases Limits: Humans / Newborn Language: En Journal: BMJ Paediatr Open Year: 2023 Document type: Article Affiliation country: Czech Republic