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Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
Maji, Arun; Soutar, Corinne P; Zhang, Jiabao; Lewandowska, Agnieszka; Uno, Brice E; Yan, Su; Shelke, Yogesh; Murhade, Ganesh; Nimerovsky, Evgeny; Borcik, Collin G; Arango, Andres S; Lange, Justin D; Marin-Toledo, Jonnathan P; Lyu, Yinghuan; Bailey, Keith L; Roady, Patrick J; Holler, Jordan T; Khandelwal, Anuj; SantaMaria, Anna M; Sanchez, Hiram; Juvvadi, Praveen R; Johns, Gina; Hageman, Michael J; Krise, Joanna; Gebremariam, Teclegiorgis; Youssef, Eman G; Bartizal, Ken; Marr, Kieren A; Steinbach, William J; Ibrahim, Ashraf S; Patterson, Thomas F; Wiederhold, Nathan P; Andes, David R; Pogorelov, Taras V; Schwieters, Charles D; Fan, Timothy M; Rienstra, Chad M; Burke, Martin D.
Affiliation
  • Maji A; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Soutar CP; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Zhang J; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Lewandowska A; Molecule Maker Lab, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Uno BE; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Yan S; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Shelke Y; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
  • Murhade G; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Nimerovsky E; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Borcik CG; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Arango AS; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Lange JD; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
  • Marin-Toledo JP; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Lyu Y; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Bailey KL; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Roady PJ; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Holler JT; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Khandelwal A; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • SantaMaria AM; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Sanchez H; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Juvvadi PR; Department for NMR-Based Structural Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
  • Johns G; Molecule Maker Lab, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Hageman MJ; National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA.
  • Krise J; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Gebremariam T; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Youssef EG; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Bartizal K; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Marr KA; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Steinbach WJ; Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
  • Ibrahim AS; Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Patterson TF; Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Wiederhold NP; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Andes DR; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Pogorelov TV; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Schwieters CD; National Institute of Child Health and Human Development, Bethesda, MD, USA.
  • Fan TM; Department of Medicine, Section of Infectious Disease, University of Wisconsin-Madison, Madison, WI, USA.
  • Rienstra CM; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Burke MD; Sfunga Therapeutics, Champaign, IL, USA.
Nature ; 623(7989): 1079-1085, 2023 Nov.
Article in En | MEDLINE | ID: mdl-37938782
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyenes / Sterols / Kidney / Antifungal Agents Limits: Animals / Humans Language: En Journal: Nature Year: 2023 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyenes / Sterols / Kidney / Antifungal Agents Limits: Animals / Humans Language: En Journal: Nature Year: 2023 Document type: Article Affiliation country: United States