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Strategic design of an NIR probe for viscosity imaging in inflammatory and non-alcoholic steatohepatitis mice.
Ma, Yaogeng; Li, Min; Sun, Huilin; Ge, Jing-Yuan; Bai, Yang; Qiu, Lin; Wu, Xuan; Chen, Jiuxi; Chen, Zhongyan.
Affiliation
  • Ma Y; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China. chenzhongyan@wzu.edu.cn.
  • Li M; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China. chenzhongyan@wzu.edu.cn.
  • Sun H; School of Pharmaceutical, Changzhou University, Changzhou 213164, P. R. China. baiy@cczu.edu.cn.
  • Ge JY; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China. chenzhongyan@wzu.edu.cn.
  • Bai Y; School of Pharmaceutical, Changzhou University, Changzhou 213164, P. R. China. baiy@cczu.edu.cn.
  • Qiu L; School of Pharmaceutical, Changzhou University, Changzhou 213164, P. R. China. baiy@cczu.edu.cn.
  • Wu X; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China. wuxuan1119@yzu.edu.cn.
  • Chen J; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China. chenzhongyan@wzu.edu.cn.
  • Chen Z; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China. chenzhongyan@wzu.edu.cn.
Chem Commun (Camb) ; 59(94): 14025-14028, 2023 Nov 23.
Article in En | MEDLINE | ID: mdl-37947054
ABSTRACT
Two novel near-infrared (NIR) fluorescent probes Cy-Vis1 and Cy-Vis2 with large Stokes shifts (>100 nm) were constructed using a "symmetry collapse" strategy. Notably, Cy-Vis2 was significantly more sensitive to viscosity than Cy-Vis1 through an enhanced intramolecular interaction strategy. The fluorescence intensities of Cy-Vis1 and Cy-Vis2 exhibited increases, by 7.6- and 19.9-fold, respectively, across the viscosity range from 0.8 cp to 359.9 cp. Cy-Vis2 was successfully used to visualize viscosity abnormalities in lipopolysaccharide (LPS)-induced inflammatory and NASH model mice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease Limits: Animals Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease Limits: Animals Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article