Polyacetylene Derivatives from the Polypore Fungus (Fistulina hepatica, Agaricomycetes) and Their Antimicrobial Activity.
Int J Med Mushrooms
; 25(12): 43-53, 2023.
Article
in En
| MEDLINE
| ID: mdl-37947063
ABSTRACT
Chemical investigation of the polypore fungus Fistulina hepatica resulted in the isolation of five compounds, including four new polyacetylenic fatty acid derivatives - isocinnatriacetin B (1), isocinnatriacetin A (2), cinna-triacetin C (3) and ethylcinnatriacetin A (4) together with one known polyacetylene fatty acid derivative - cinnatriacetin A (5). The structures were elucidated using spectroscopic methods (UV, NMR, HR-ESIMS) along with comparison to literature data. Antibacterial activity screening of compounds 1-5 against ESKAPE bacterial strains in vitro with zones of inhibition (ZOI) was performed and MIC values were established for the most active compounds (3 and 4). Together with that morphological and growth parameters under solid-phase cultivation were also researched.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Basidiomycota
/
Agaricales
Language:
En
Journal:
Int J Med Mushrooms
Year:
2023
Document type:
Article