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Inhaled paraquat-induced lung injury in rat, improved by the extract of Zataria multiflora boiss and PPARγ agonist, pioglitazone.
Amin, Fatemeh; Memarzia, Arghavan; Kazemi Rad, Hamideh; Kazerani, Hamid Reza; Ghasemi, Seyedeh Zahra; Boskabady, Mohammad Hossein.
Affiliation
  • Amin F; Department of Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
  • Memarzia A; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Kazemi Rad H; Department of Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address: kazerani@yahoo.co.uk.
  • Kazerani HR; Department of Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
  • Ghasemi SZ; Department of Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
  • Boskabady MH; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: boskabadymh@mums.ac.ir.
Leg Med (Tokyo) ; 67: 102335, 2024 Mar.
Article in En | MEDLINE | ID: mdl-37951808
The effects of a PPAR-γ agonist, pioglitazone and Zataria multiflora (Z. multiflora) on inhaled paraquat (PQ)-induced lung oxidative stress, inflammation, pathological changes and tracheal responsiveness were examined. The study was carried out in control rats exposed to normal aerosol of saline, PQl and PQh groups exposed to aerosols of 27 and 54 mg/m3 PQ, groups exposed to high PQ concentration (PQh) and treated with 200 and 800 mg/kg/day Z. multiflora, 5 and 10 mg/kg/day pioglitazone, low doses of Z. multiflora + pioglitazone, and 0.03 mg/kg/day dexamethasone. Increased tracheal responsiveness, transforming growth factor beta (TGF-ß) and lung pathological changes due to PQh were significantly improved by high doses of Z. multiflora and pioglitazone, dexamethasone and extract + pioglitazone, (p < 0.05 to p < 0.001). In group treated with low doses of the extract + pioglitazone, the improvements of most measured variables were significantly higher than the low dose of two agents alone (p < 0.05 to p < 0.001). Z. multiflora improved lung injury induced by inhaled PQ similar to dexamethasone and pioglitazone which could be mediated by PPAR-γ receptor.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paraquat / Lung Injury Limits: Animals Language: En Journal: Leg Med (Tokyo) Journal subject: JURISPRUDENCIA Year: 2024 Document type: Article Affiliation country: Iran Country of publication: Ireland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paraquat / Lung Injury Limits: Animals Language: En Journal: Leg Med (Tokyo) Journal subject: JURISPRUDENCIA Year: 2024 Document type: Article Affiliation country: Iran Country of publication: Ireland