Perioperative Extracellular Brain Free-Water Changes for Older Adults Electing Total Knee Arthroplasty with General versus Spinal Anesthesia: A Pilot Study.
J Alzheimers Dis
; 96(3): 1243-1252, 2023.
Article
in En
| MEDLINE
| ID: mdl-37955084
ABSTRACT
BACKGROUND:
Recent research shows that older adults electing to undergo total knee arthroplasty with general anesthesia have a pre- to postoperative acute increase in molecular free-water within their cerebral white matter. It is unknown if this change is similar for individuals who elect spinal anesthesia methods.OBJECTIVE:
To explore white matter microstructural changes in a pilot sample of older adults undergoing total knee arthroplasty and receiving general or spinal anesthesia.METHODS:
We assessed acute perioperative changes in brain white matter free-water in a limited number of older adults electing total knee arthroplasty under spinal anesthesia (nâ=â5) and matched groups of older adults who received general anesthesia (nâ=â5) or had no surgery (nâ=â5). Patterns of free-water changes were also compared in the larger group of older adults electing total knee arthroplasty under general anesthesia (nâ=â61) and older adults with chronic knee pain who received no surgical intervention (nâ=â65).RESULTS:
Our pilot results suggest older adults receiving general anesthesia had pre- to post-surgery free-water increases extensively throughout their white matter whereas those receiving spinal anesthesia appeared to have less consistent free-water increases.CONCLUSIONS:
Our pilot results possibly suggest different patterns of perioperative brain white matter free-water changes based on anesthetic approach. We recommend future, larger studies to further examine the effects of anesthetic approach on perioperative brain free-water. The results of our study have potential implications for acute and chronic cognitive changes, perioperative complications, neurodegenerative processes including Alzheimer's disease, and understanding neuroinflammation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthroplasty, Replacement, Knee
/
Anesthesia, Spinal
/
Anesthetics
Limits:
Aged
/
Humans
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2023
Document type:
Article
Affiliation country:
United States