The phage-encoded PIT4 protein affects multiple two-component systems of Pseudomonas aeruginosa.
Microbiol Spectr
; 11(6): e0237223, 2023 Dec 12.
Article
in En
| MEDLINE
| ID: mdl-37962408
ABSTRACT
IMPORTANCE More and more Pseudomonas aeruginosa isolates have become resistant to antibiotics like carbapenem. As a consequence, P. aeruginosa ranks in the top three of pathogens for which the development of novel antibiotics is the most crucial. The pathogen causes both acute and chronic infections, especially in patients who are the most vulnerable. Therefore, efforts are urgently needed to develop alternative therapies. One path explored in this article is the use of bacteriophages and, more specifically, phage-derived proteins. In this study, a phage-derived protein was studied that impacts key virulence factors of the pathogen via interaction with multiple histidine kinases of TCSs. The fundamental insights gained for this protein can therefore serve as inspiration for the development of an anti-virulence compound that targets the bacterial TCS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas Infections
/
Bacteriophages
Limits:
Humans
Language:
En
Journal:
Microbiol Spectr
Year:
2023
Document type:
Article
Affiliation country:
Belgium