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Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free-Wilson Analysis for Improved In Vivo Efficacy.
Murphy, Sean T; Atienza, Joy; Brown, Jason W; Cheruvallath, Zacharia S; Cukierski, Matthew J; Fabrey, Robyn; Keung, Walter; Kwok, Lily; O'Connell, Shawn; Tang, Mingnam; Vanderpool, Darin L; Vincent, Patrick W; Zhang, Lilly; Marx, Matthew A.
Affiliation
  • Murphy ST; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Atienza J; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Brown JW; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Cheruvallath ZS; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Cukierski MJ; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Fabrey R; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Keung W; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Kwok L; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • O'Connell S; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Tang M; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Vanderpool DL; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Vincent PW; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Zhang L; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Marx MA; Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, United States.
ACS Med Chem Lett ; 14(11): 1544-1550, 2023 Nov 09.
Article in En | MEDLINE | ID: mdl-37970587
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2023 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2023 Document type: Article Affiliation country: United States