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Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Bordeleau, Emily; Stogios, Peter J; Evdokimova, Elena; Koteva, Kalinka; Savchenko, Alexei; Wright, Gerard D.
Affiliation
  • Bordeleau E; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Stogios PJ; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Evdokimova E; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Koteva K; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Savchenko A; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Wright GD; Center for Structural Genomics of Infectious Diseases (CSGID) University of Calgary, Calgary, Alberta, Canada.
Nat Chem Biol ; 20(2): 234-242, 2024 Feb.
Article in En | MEDLINE | ID: mdl-37973888
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aminoglycosides / Histidine Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2024 Document type: Article Affiliation country: Canada Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aminoglycosides / Histidine Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2024 Document type: Article Affiliation country: Canada Country of publication: United States