Synthesis, biological evaluation, and computational studies of <i>N</i>-benzyl pyridinium-curcumin derivatives as potent AChE inhibitors with antioxidant activity.

Al-Rifai, Nafisah M; Al-Khalileh, Nemeh M; Zahra, Jalal A; El-Barghouthi, Musa I; Darras, Fouad H

Synthesis, biological evaluation, and computational studies of N-benzyl pyridinium-curcumin derivatives as potent AChE inhibitors with antioxidant activity.

Al-Rifai, Nafisah M; Al-Khalileh, Nemeh M; Zahra, Jalal A; El-Barghouthi, Musa I; Darras, Fouad H.

Affiliation

Al-Rifai NM; Pharmaceutical-Chemical Engineering Department, School of Medical Sciences, German Jordanian University, P.O. Box 35247, Amman 11180, Jordan.
Al-Khalileh NM; Chemistry Department, The University of Jordan, Amman, Jordan.
Zahra JA; Chemistry Department, The University of Jordan, Amman, Jordan.
El-Barghouthi MI; Department of Chemistry, Faculty of Science, The Hashemite University, Zarqa 13133, Jordan.
Darras FH; Resonance Research Lab, Amman, Jordan.

J Enzyme Inhib Med Chem ; 38(1): 2281264, 2023 Dec.

Article in En | MEDLINE | ID: mdl-37985494

Subject(s)

Alzheimer Disease; Curcumin; Humans; Donepezil; Cholinesterase Inhibitors/pharmacology; Antioxidants/pharmacology; Structure-Activity Relationship; Acetylcholinesterase/metabolism; Pain; Molecular Docking Simulation

Key words

Acetylcholinesterase inhibitors; Alzheimer's disease; antioxidants; docking study; pyridinium; synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Curcumin / Alzheimer Disease Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Document type: Article Affiliation country: Jordan

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