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Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases.
Garrison, McKinzie A; Jang, Yeongjun; Bae, Taejeong; Cherskov, Adriana; Emery, Sarah B; Fasching, Liana; Jones, Attila; Moldovan, John B; Molitor, Cindy; Pochareddy, Sirisha; Peters, Mette A; Shin, Joo Heon; Wang, Yifan; Yang, Xiaoxu; Akbarian, Schahram; Chess, Andrew; Gage, Fred H; Gleeson, Joseph G; Kidd, Jeffrey M; McConnell, Michael; Mills, Ryan E; Moran, John V; Park, Peter J; Sestan, Nenad; Urban, Alexander E; Vaccarino, Flora M; Walsh, Christopher A; Weinberger, Daniel R; Wheelan, Sarah J; Abyzov, Alexej.
Affiliation
  • Garrison MA; Program in Biochemistry, Molecular and Cellular Biology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
  • Jang Y; Department of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
  • Bae T; Department of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
  • Cherskov A; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.
  • Emery SB; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
  • Fasching L; Child Study Center, Yale University, New Haven, CT, 06520, USA.
  • Jones A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Moldovan JB; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Molitor C; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
  • Pochareddy S; Sage Bionetworks, 2901 Third Ave., Suite 330, Seattle, WA, 98121, USA.
  • Peters MA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.
  • Shin JH; Sage Bionetworks, 2901 Third Ave., Suite 330, Seattle, WA, 98121, USA.
  • Wang Y; Lieber Institute for Brain Development, Baltimore, MD, 21205, USA.
  • Yang X; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Akbarian S; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
  • Chess A; Rady Children's Institute for Genomic Medicine, 7910 Frost St., Suite #300, San Diego, CA, 92123, USA.
  • Gage FH; Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
  • Gleeson JG; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kidd JM; Icahn Institute for Data Science and Genomic Technologies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • McConnell M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Mills RE; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Moran JV; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Park PJ; Icahn Institute for Data Science and Genomic Technologies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sestan N; Laboratory of Genetics LOG-G, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.
  • Urban AE; Rady Children's Institute for Genomic Medicine, 7910 Frost St., Suite #300, San Diego, CA, 92123, USA.
  • Vaccarino FM; Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
  • Walsh CA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
  • Weinberger DR; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA.
  • Wheelan SJ; Lieber Institute for Brain Development, Baltimore, MD, 21205, USA.
  • Abyzov A; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Sci Data ; 10(1): 813, 2023 11 20.
Article in En | MEDLINE | ID: mdl-37985666
ABSTRACT
Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mental Disorders Limits: Humans Language: En Journal: Sci Data Year: 2023 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mental Disorders Limits: Humans Language: En Journal: Sci Data Year: 2023 Document type: Article Affiliation country: United States