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Machine Learning Technology for EEG-Forecast of the Blood-Brain Barrier Leakage and the Activation of the Brain's Drainage System during Isoflurane Anesthesia.
Semyachkina-Glushkovskaya, Oxana; Sergeev, Konstantin; Semenova, Nadezhda; Slepnev, Andrey; Karavaev, Anatoly; Hramkov, Alexey; Prokhorov, Mikhail; Borovkova, Ekaterina; Blokhina, Inna; Fedosov, Ivan; Shirokov, Alexander; Dubrovsky, Alexander; Terskov, Andrey; Manzhaeva, Maria; Krupnova, Valeria; Dmitrenko, Alexander; Zlatogorskaya, Daria; Adushkina, Viktoria; Evsukova, Arina; Tuzhilkin, Matvey; Elizarova, Inna; Ilyukov, Egor; Myagkov, Dmitry; Tuktarov, Dmitry; Kurths, Jürgen.
Affiliation
  • Semyachkina-Glushkovskaya O; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Sergeev K; Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany.
  • Semenova N; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Slepnev A; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Karavaev A; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Hramkov A; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Prokhorov M; Institute of Radio Engineering and Electronics of RAS, Zelenaya Str. 38, 410019 Saratov, Russia.
  • Borovkova E; Research Institute of Cardiology, Saratov State Medical University, B. Kazachaya Str. 112, 410012 Saratov, Russia.
  • Blokhina I; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Fedosov I; Institute of Radio Engineering and Electronics of RAS, Zelenaya Str. 38, 410019 Saratov, Russia.
  • Shirokov A; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Dubrovsky A; Institute of Radio Engineering and Electronics of RAS, Zelenaya Str. 38, 410019 Saratov, Russia.
  • Terskov A; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Manzhaeva M; Institute of Radio Engineering and Electronics of RAS, Zelenaya Str. 38, 410019 Saratov, Russia.
  • Krupnova V; Research Institute of Cardiology, Saratov State Medical University, B. Kazachaya Str. 112, 410012 Saratov, Russia.
  • Dmitrenko A; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Zlatogorskaya D; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Adushkina V; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Evsukova A; Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Prospekt Entuziastov 13, 410049 Saratov, Russia.
  • Tuzhilkin M; Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Elizarova I; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Ilyukov E; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Myagkov D; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Tuktarov D; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
  • Kurths J; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Biomolecules ; 13(11)2023 11 02.
Article in En | MEDLINE | ID: mdl-38002287
ABSTRACT
Anesthesia enables the painless performance of complex surgical procedures. However, the effects of anesthesia on the brain may not be limited only by its duration. Also, anesthetic agents may cause long-lasting changes in the brain. There is growing evidence that anesthesia can disrupt the integrity of the blood-brain barrier (BBB), leading to neuroinflammation and neurotoxicity. However, there are no widely used methods for real-time BBB monitoring during surgery. The development of technologies for an express diagnosis of the opening of the BBB (OBBB) is a challenge for reducing post-surgical/anesthesia consequences. In this study on male rats, we demonstrate a successful application of machine learning technology, such as artificial neural networks (ANNs), to recognize the OBBB induced by isoflurane, which is widely used in surgery. The ANNs were trained on our previously presented data obtained on the sound-induced OBBB with an 85% testing accuracy. Using an optical and nonlinear analysis of the OBBB, we found that 1% isoflurane does not induce any changes in the BBB, while 4% isoflurane caused significant BBB leakage in all tested rats. Both 1% and 4% isoflurane stimulate the brain's drainage system (BDS) in a dose-related manner. We show that ANNs can recognize the OBBB induced by 4% isoflurane in 57% of rats and BDS activation induced by 1% isoflurane in 81% of rats. These results open new perspectives for the development of clinically significant bedside technologies for EEG-monitoring of OBBB and BDS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anesthetics, Inhalation / Isoflurane / Anesthesia Limits: Animals Language: En Journal: Biomolecules Year: 2023 Document type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anesthetics, Inhalation / Isoflurane / Anesthesia Limits: Animals Language: En Journal: Biomolecules Year: 2023 Document type: Article Affiliation country: RUSSIA