Neuropsychiatric Symptoms and In Vivo Alzheimer's Biomarkers in Mild Cognitive Impairment.
J Alzheimers Dis
; 96(4): 1827-1836, 2023.
Article
in En
| MEDLINE
| ID: mdl-38007644
ABSTRACT
BACKGROUND:
Neuropsychiatric symptoms (NPS) carry an increased risk of progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). There is a need to understand how to integrate NPS into the paradigm outlined in the 2018 NIA-AA Research Framework.OBJECTIVE:
To evaluate a prediction model of MCI-AD progression using a collection of variables, including NPS, cognitive testing, apolipoprotein E4 status (APOE4), imaging and laboratory AD biomarkers.METHODS:
Of 300 elderly subjects, 219 had stable MCI and 81 MCI-AD progression over a 5-year follow-up. NPS were measured using the Neuropsychiatric Inventory (NPI). A multivariate Cox Proportional Hazards Regression Analysis assessed the effects of APOE4, baseline NPI, baseline CSF amyloid-ß, phosphorylated and total tau, baseline AD-signature MRI biomarker, baseline memory and executive function on MCI-AD progression.RESULTS:
27% progressed to dementia (median follow-upâ=â43 months). NPS were found in stable MCI (62.6%) and MCI-AD converters (70.3%). The Cox model exhibited a good fit (pâ<â0.001), and NPS (HRâ=â1.033, pâ=â0.027), phosphorylated tau (HRâ=â1.011, pâ=â0.025), total tau (HRâ=â1.005, pâ=â0.024), AD-signature MRI biomarker (HRâ=â0.111, pâ=â0.002), executive function (HRâ=â0.727, pâ=â0.045), and memory performance (HRâ=â0.387, pâ<â0.001) were significantly associated with dementia.CONCLUSIONS:
NPS may inform dementia risk assessment in conjunction with cognitive testing and imaging and laboratory AD biomarkers. NPS is independently associated with the risk of MCI-dementia progression, over and beyond the contributions of CSF biomarkers.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alzheimer Disease
/
Cognitive Dysfunction
Limits:
Aged
/
Humans
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2023
Document type:
Article
Affiliation country:
United States