[Advances in molecular mechanism and treatment of chronic mucus hypersecretion].
Zhonghua Jie He He Hu Xi Za Zhi
; 46(12): 1272-1278, 2023 Dec 12.
Article
in Zh
| MEDLINE
| ID: mdl-38044058
ABSTRACT
Chronic obstructive pulmonary disease (COPD) is one of the chronic diseases with high morbidity and mortality in China, which imposes heavy economic burden on society. Research has shown that chronic mucus hypersecretion (CMH) is an independent risk factor for persistent clinical symptoms, poor quality of life, rapid decline in lung function, acute exacerbation and increased hospitalization rate in COPD patients. CMH is a clinical phenotype of COPD with specific pathological and physiological changes. At present, the formation mechanism of CMH is not clear. There is a lack of specific and effective targeted treatments. This article aimed to review the latest research findings on CMH at home and abroad from the overview, impact on COPD patients, molecular mechanisms of formation, current treatment status and progress, and discuss potential targets for CMH treatment, to provide new ideas and directions for improving CMH and treating COPD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quality of Life
/
Pulmonary Disease, Chronic Obstructive
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Jie He He Hu Xi Za Zhi
Year:
2023
Document type:
Article
Affiliation country:
China