Osteoimmunology: Interactions With the Immune System in Spinal Fusion.
Int J Spine Surg
; 17(S3): S9-S17, 2023 Dec 27.
Article
in En
| MEDLINE
| ID: mdl-38050073
ABSTRACT
Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the osteogenic, osteoconductive, and osteoinductive properties of bone grafts and substitutes and ultimately influences the success of spinal fusion. Macrophages have emerged as important cells for coordinating the immune response following spinal fusion surgery, and macrophage-derived cytokines impact each phase of bone graft healing. This review explores the cellular and molecular immune processes that regulate bone homeostasis and healing during spinal fusion.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Int J Spine Surg
Year:
2023
Document type:
Article
Affiliation country:
United States