Use of sacubitril/valsartan in patients with heart failure: evidence from the real world.
Expert Opin Pharmacother
; 24(18): 2211-2219, 2023.
Article
in En
| MEDLINE
| ID: mdl-38051633
ABSTRACT
BACKGROUND:
To characterize the use of sacubitril/valsartan in a group of patients with heart failure in Colombia. RESEARCH DESIGN ANDMETHODS:
Follow-up study of patients with heart failure who started sacubitril/valsartan and were affiliated with the Colombian health system between 2019 and 2021. Sociodemographic, clinical, and pharmacological variables and adherence and persistence of use were identified.RESULTS:
A total of 514 patients were identified, with a mean age of 65.7 years, 73.7% of whom started sacubitril/valsartan at low doses, and only 12.5% reached the maximum dose. Adherence was 78.2% and persistence was 56.8% at 1 year of follow-up. The increase in systolic blood pressure (odds ratio (OR) 1.01; 95% CI 1.00-1.03) and the use of ß-blockers (OR 2.63; 95% CI 1.42-4.85) were correlated with a greater persistence, while receiving furosemide (OR 0.59; 95% CI 0.39-0.89) and not having received renin - angiotensin - aldosterone system inhibitors in the 3 months before starting sacubitril/valsartan (OR 0.48; 95% CI 0.31-0.76) were associated with lower persistence.CONCLUSIONS:
The persistence of treatment 1 year after starting sacubitril/valsartan was not high, and a small proportion of patients reached the target dose of the drug. Nontitration of the drug dose was common.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tetrazoles
/
Heart Failure
Limits:
Aged
/
Humans
Language:
En
Journal:
Expert Opin Pharmacother
Journal subject:
FARMACOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
Colombia