Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity.
Nat Nanotechnol
; 19(3): 387-398, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38052943
ABSTRACT
Trained immunity enhances the responsiveness of immune cells to subsequent infections or vaccinations. Here we demonstrate that pre-vaccination with bacteria-derived outer-membrane vesicles, which contain large amounts of pathogen-associated molecular patterns, can be used to potentiate, and enhance, tumour vaccination by trained immunity. Intraperitoneal administration of these outer-membrane vesicles to mice activates inflammasome signalling pathways and induces interleukin-1ß secretion. The elevated interleukin-1ß increases the generation of antigen-presenting cell progenitors. This results in increased immune response when tumour antigens are delivered, and increases tumour-antigen-specific T-cell activation. This trained immunity increased protection from tumour challenge in two distinct cancer models.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trained Immunity
/
Neoplasms
Limits:
Animals
Language:
En
Journal:
Nat Nanotechnol
Year:
2024
Document type:
Article
Affiliation country:
China