Oxidative and ER stress by elevated insulin biosynthesis and palmitic acid in insulin-producing cells.

Vidrio-Huerta, Brenda; Plötz, Thomas; Lortz, Stephan

Vidrio-Huerta, Brenda; Plötz, Thomas; Lortz, Stephan.

Affiliation

Vidrio-Huerta B; Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.
Plötz T; Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.
Lortz S; Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.

J Mol Endocrinol ; 72(2)2024 Feb 01.

Article in En | MEDLINE | ID: mdl-38054640

Subject(s)

Diabetes Mellitus, Type 2; Insulin Resistance; Insulin-Secreting Cells; Humans; Palmitic Acid/pharmacology; Catalase/metabolism; Catalase/pharmacology; Diabetes Mellitus, Type 2/metabolism; Hydrogen Peroxide/pharmacology; Insulin-Secreting Cells/metabolism; Insulin/metabolism; Apoptosis; Oxidative Stress; Endoplasmic Reticulum Stress

Key words

catalase; endoplasmic reticulum; gluco-lipotoxicity; insulin-secreting cells; palmitic acid; protein folding; reactive oxygen species

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Diabetes Mellitus, Type 2 / Insulin-Secreting Cells Limits: Humans Language: En Journal: J Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2024 Document type: Article Affiliation country: Germany

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