Real-world experience with brolucizumab in neovascular age-related macular degeneration over 2 years: the REBA extension study.
Graefes Arch Clin Exp Ophthalmol
; 262(4): 1161-1167, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38063874
ABSTRACT
BACKGROUND:
To determine long-term efficacy and safety of intravitreal brolucizumab therapy for neovascular age-related macular degeneration (nAMD) in the real-world setting.METHODS:
Retrospective, observational, multicentric study and an extension of the REBA study (Real-world Experience with Brolucizumab in nAMD) to 24 months. The study entailed follow-up of 91 consecutive eyes (67 patients) with nAMD who received brolucizumab therapy and completed 24 months of follow-up. Both treatment-naïve and switch therapy patients were included. All relevant data were collected. The primary outcome measure was changed in best-corrected visual acuity (BCVA) over time. Secondary outcome measures included change in central subfield thickness (CST) and complications.RESULTS:
The mean (SD) baseline BCVA was 48.4 (3.5) letters and 36.2 (7.1) letters in treatment-naïve group and switch therapy group, respectively. BCVA gain was + 9.2 (3.7) letters (p = 0.01) and + 7.7 (3.4) letters (p = 0.011), respectively. The change in mean (SD) CST has shown a significant decrease in retinal thickness in treatment-naïve group (from 432.5 (68.4) to 283.0 (51.3) µm; p = 0.018) and in switch therapy group (from 452.5 (40.5) to 271.0 (43.4) µm; p = 0.011) group. One switch patient developed vascular occlusion and another a macular hole after the fifth brolucizumab injection as reported in the primary study. Both patients recovered uneventfully. Three patients demonstrated reversible intraocular inflammation between months 10 and 24.CONCLUSION:
Patients showed a significant anatomical and functional response to brolucizumab therapy in the real world, regardless of prior treatment status, until the end of the follow-up period. Overall, 5 significant untoward events were noted.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wet Macular Degeneration
/
Macular Degeneration
Limits:
Child, preschool
/
Humans
Language:
En
Journal:
Graefes Arch Clin Exp Ophthalmol
Year:
2024
Document type:
Article
Affiliation country:
Germany