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Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration.
Ishitsubo, Naoki; Oguro, Shinji; Shimahashi, Hirotoshi; Kawanishi, Masato; Adachi, Takeshi; Mitsuda, Kenji; Ishibashi, Nobuyuki.
Affiliation
  • Ishitsubo N; Production Technology Division, Production Headquarters, Nippon Zoki Pharmaceutical Co., Ltd., 1093-1, Minamiyama Furukawa-cho, Ono, 675-1363, Japan.
  • Oguro S; Drug Safety & Quality Assurance Division, Nippon Zoki Pharmaceutical Co., Ltd., 4-2-3 Hiranomachi, Chuo-Ku, Osaka, 541-0046, Japan.
  • Shimahashi H; Production Management Division, Production Headquarters, Nippon Zoki Pharmaceutical Co., Ltd., 4-2-3 Hiranomachi, Chuo-Ku, Osaka, 541-0046, Japan. h-shimahashi@nippon-zoki.co.jp.
  • Kawanishi M; China Sales / Development Office, Nippon Zoki Pharmaceutical Co., Ltd., 4-2-3 Hiranomachi, Chuo-Ku, Osaka, 541-0046, Japan.
  • Adachi T; Biostat & CDM Section, Division II, Development Department, R&D Management Headquarters, Nippon Zoki Pharmaceutical Co., Ltd., 4-2-3 Hiranomachi, Chuo-Ku, Osaka, 541-0046, Japan.
  • Mitsuda K; Quality Assurance Department, Ono Ryokuen Factory, Production Headquarters, Nippon Zoki Pharmaceutical Co., Ltd., 1093-1, Minamiyama Furukawa-cho, Ono, 675-1363, Japan.
  • Ishibashi N; Development Division, Kozaike Kohsan Co.,Ltd., 10-8, Hiroshiba-Cho, Suita-shi, Osaka, 564-0052, Japan.
Eur J Drug Metab Pharmacokinet ; 49(1): 87-100, 2024 Jan.
Article in En | MEDLINE | ID: mdl-38064122
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tramadol Limits: Adult / Humans / Male Language: En Journal: Eur J Drug Metab Pharmacokinet Year: 2024 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tramadol Limits: Adult / Humans / Male Language: En Journal: Eur J Drug Metab Pharmacokinet Year: 2024 Document type: Article Affiliation country: Japan