Metformin Suppresses Stemness of Non-Small-Cell Lung Cancer Induced by Paclitaxel through FOXO3a.

Tang, Zhimin; Zhang, Yilan; Yu, Zhengyi; Luo, Zhijun

Tang, Zhimin; Zhang, Yilan; Yu, Zhengyi; Luo, Zhijun.

Affiliation

Tang Z; Jiangxi Provincial Key Laboratory of Tumor Pathogens and Molecular Pathology, Department of Pathophysiology, School of Basic Medical Sciences, Nanchang University, Nanchang 330031, China.
Zhang Y; Nanchang Joint Program, Queen Mary School, Nanchang University, Nanchang 330031, China.
Yu Z; Nanchang Joint Program, Queen Mary School, Nanchang University, Nanchang 330031, China.
Luo Z; Jiangxi Provincial Key Laboratory of Tumor Pathogens and Molecular Pathology, Department of Pathophysiology, School of Basic Medical Sciences, Nanchang University, Nanchang 330031, China.

Int J Mol Sci ; 24(23)2023 Nov 22.

Article in En | MEDLINE | ID: mdl-38068934

Subject(s)

Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Metformin; Humans; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/metabolism; Paclitaxel/pharmacology; Paclitaxel/therapeutic use; Metformin/pharmacology; Metformin/therapeutic use; Proto-Oncogene Proteins c-akt/metabolism; AMP-Activated Protein Kinases/metabolism; Lung Neoplasms/drug therapy; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Cell Line, Tumor; Mitogen-Activated Protein Kinase Kinases; Cell Proliferation; Drug Resistance, Neoplasm

Key words

FOXO3a; NSCLC; metformin; paclitaxel (PTX); stemness

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms / Metformin Limits: Humans Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country: China Country of publication: Switzerland

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