Mpox vaccination and treatment: a systematic review.
J Chemother
; 36(2): 85-109, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38069596
ABSTRACT
The Human monkeypox virus (mpox) belongs to the Poxviridae family, characterized by double-stranded DNA. A 2022 outbreak, notably prevalent among men who have sex with men, was confirmed by the World Health Organization. To understand shifting prevalence patterns and clinical manifestations, we conducted a systematic review of recent animal and human studies. We comprehensively searched PubMed, Scopus, Web of Science, Cochrane Library, and Clinicaltrials.gov, reviewing 69 relevant articles from 4,342 screened records. Our analysis highlights Modified Vaccinia Ankara - Bavarian Nordic (MVA-BN)'s potential, though efficacy concerns exist. Tecovirimat emerged as a prominent antiviral in the recent outbreak. However, limited evidence underscores the imperative for further clinical trials in understanding and managing monkeypox.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Smallpox Vaccine
/
Mpox (monkeypox)
Type of study:
Systematic_reviews
Limits:
Animals
/
Humans
Language:
En
Journal:
J Chemother
Journal subject:
ANTINEOPLASICOS
/
TERAPIA POR MEDICAMENTOS
Year:
2024
Document type:
Article
Affiliation country:
Iran