Development and validation of a sensitive UPLC-MS/MS analytical method for GFH009 in rat plasma and its application to toxicokinetics studies.

Liu, Qiang; Zhao, Jin-Zhu; Zhou, Fu-Sheng; Lan, Jiong; Lu, Qiang; Ren, Hong-Can

Liu, Qiang; Zhao, Jin-Zhu; Zhou, Fu-Sheng; Lan, Jiong; Lu, Qiang; Ren, Hong-Can.

Affiliation

Liu Q; GenFleet Therapeutics (Shanghai) Inc., Shanghai, P. R. China.
Zhao JZ; GenFleet Therapeutics (Shanghai) Inc., Shanghai, P. R. China.
Zhou FS; GenFleet Therapeutics (Shanghai) Inc., Shanghai, P. R. China.
Lan J; GenFleet Therapeutics (Shanghai) Inc., Shanghai, P. R. China.
Lu Q; GenFleet Therapeutics (Shanghai) Inc., Shanghai, P. R. China.
Ren HC; GenFleet Therapeutics (Shanghai) Inc., Shanghai, P. R. China.

Biomed Chromatogr ; 38(2): e5788, 2024 Feb.

Article in En | MEDLINE | ID: mdl-38081587

Subject(s)

Liquid Chromatography-Mass Spectrometry; Tandem Mass Spectrometry; Rats; Animals; Tandem Mass Spectrometry/methods; Rats, Sprague-Dawley; Chromatography, Liquid; Toxicokinetics; Chromatography, High Pressure Liquid/methods; Protein Kinase Inhibitors; Reproducibility of Results

Key words

CDK9 inhibitor; UHPLC-MS/MS; toxicokinetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tandem Mass Spectrometry / Liquid Chromatography-Mass Spectrometry Limits: Animals Language: En Journal: Biomed Chromatogr Year: 2024 Document type: Article Country of publication: United kingdom

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