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Antifungal susceptibility profile and local epidemiological cut-off values of Yarrowia (Candida) lipolytica: an emergent and rare opportunistic yeast.
Yu, Jinhan; Liu, Xueqing; Guo, Dawen; Yang, Wenhang; Chen, Xinfei; Zou, Guiling; Wang, Tong; Pang, Shichao; Zhang, Ge; Dong, Jingjing; Xu, Yingchun; Zhao, Ying.
Affiliation
  • Yu J; Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing, China.
  • Liu X; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing, China.
  • Guo D; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing, China.
  • Yang W; Department of Clinical Laboratory, Yongzhou Central Hospital , Yongzhou, China.
  • Chen X; Department of Microbiology, the First Affiliated Hospital, Harbin Medical University , Harbin, China.
  • Zou G; Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing, China.
  • Wang T; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing, China.
  • Pang S; Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing, China.
  • Zhang G; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing, China.
  • Dong J; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing, China.
  • Xu Y; Department of Microbiology, the Fourth Affiliated Hospital, Harbin Medical University , Harbin, China.
  • Zhao Y; Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing, China.
Microbiol Spectr ; 12(1): e0320323, 2024 Jan 11.
Article in En | MEDLINE | ID: mdl-38084981
IMPORTANCE: Yarrowia lipolytica, also known as Candida lipolytica, is an emerging opportunistic "rare pathogenic yeast". Due to the limited data on its antifungal susceptibility, the clinical treatments become challenging. Based on the China Hospital Invasive Fungal Surveillance Network (2009-2022), we conducted a comprehensive multi-method study on clinical isolates from various central hospitals. This study is currently the largest study carried out to assess the antifungal susceptibility of Y. lipolytica. It is also the first to establish local epidemiological cut-off values (L-ECOFFs), identify its ERG11 mutations, and assess the consistency between the three prevalent commercial antifungal susceptibility testing methods and the broth microdilution method. We recommend the Sensititre YeastOne as the best option for antifungal susceptibility testing for Y. lipolytica, followed by the ATB FUNGUS 3. Nevertheless, practitioners should use the MIC test strip with discretion.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Yarrowia / Antifungal Agents Country/Region as subject: Asia Language: En Journal: Microbiol Spectr Year: 2024 Document type: Article Affiliation country: China Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Yarrowia / Antifungal Agents Country/Region as subject: Asia Language: En Journal: Microbiol Spectr Year: 2024 Document type: Article Affiliation country: China Country of publication: United States