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Discovery of Orally Available and Brain Penetrant AEP Inhibitors.
Krummenacher, Daniela; He, Weiping; Kuhn, Bernd; Schnider, Christian; Beurier, Angélica; Brom, Virginie; Sivasothy, Thulase; Marty, Christine; Tosstorff, Andreas; Hewings, David S; Mesch, Stefanie; Pinard, Emmanuel; Brändlin, Mathis; Hochstrasser, Remo; Westwood, Paul; Rothe, Judith; Kronenberger, Alexandra; Morandi, Federica; Gutbier, Simon; Schuler, Angelika; Heer, Dominik; Gloria, Ludivine Esteves; Joedicke, Lisa; Rudolph, Markus G; Müller, Lutz; Grüninger, Fiona; Baumann, Karlheinz; Kaniyappan, Senthilvelrajan; Manevski, Nenad; Bartels, Björn.
Affiliation
  • Krummenacher D; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • He W; WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-Tech Development Zone, 666 GaoXin Road, Wuhan, Hubei 430075, China.
  • Kuhn B; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Schnider C; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Beurier A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Brom V; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Sivasothy T; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Marty C; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Tosstorff A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Hewings DS; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Mesch S; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Pinard E; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Brändlin M; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Hochstrasser R; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Westwood P; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Rothe J; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Kronenberger A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Morandi F; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Gutbier S; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Schuler A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Heer D; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Gloria LE; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Joedicke L; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Rudolph MG; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Müller L; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Grüninger F; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Baumann K; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Kaniyappan S; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Manevski N; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
  • Bartels B; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel CH-4070, Switzerland.
J Med Chem ; 66(24): 17026-17043, 2023 12 28.
Article in En | MEDLINE | ID: mdl-38090813
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tau Proteins / Alzheimer Disease Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Switzerland Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tau Proteins / Alzheimer Disease Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Switzerland Country of publication: United States