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Characterizing Macular Neovascularization in Myopic Macular Degeneration and Age-Related Macular Degeneration Using Swept Source OCTA.
Sayah, Diane N; Garg, Itika; Katz, Raviv; Zhu, Ying; Cui, Ying; Zeng, Rebecca; Tandias, Rachel; Moon, Jade Y; Vingopoulos, Filippos; Wescott, Hannah E; Baldwin, Grace; Wang, Kira; Elze, Tobias; Ludwig, Cassie Ann; Vavvas, Demetrios G; Miller, Joan W; Husain, Deeba; Kim, Leo A; Patel, Nimesh A; Miller, John B.
Affiliation
  • Sayah DN; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Garg I; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Katz R; College of Optometry, University of Houston, Houston, TX, USA.
  • Zhu Y; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Cui Y; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Zeng R; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Tandias R; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Moon JY; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Vingopoulos F; Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
  • Wescott HE; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Baldwin G; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
  • Wang K; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Elze T; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Ludwig CA; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Vavvas DG; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Miller JW; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Husain D; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Kim LA; Harvard Retinal Imaging Lab, Boston, MA, USA.
  • Patel NA; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • Miller JB; Harvard Retinal Imaging Lab, Boston, MA, USA.
Clin Ophthalmol ; 17: 3855-3866, 2023.
Article in En | MEDLINE | ID: mdl-38105914
ABSTRACT

Purpose:

Visual prognosis and treatment burden for macular neovascularization (MNV) can differ between myopic macular degeneration (MMD) and age-related macular degeneration (AMD). We describe and compare MNV associated with MMD and AMD using swept-source (SS)-OCTA. Patients and

Methods:

Adult patients with documented MNV associated with MMD or AMD were consecutively recruited. Qualitative and quantitative features were assessed from 6x6mm angiograms, including the MNV area and vessel density (VD). Descriptive statistics and linear regression analyses were carried out.

Results:

Out of 75 enrolled eyes with diagnosed MNV (30 MMD-MNV and 45 AMD-MNV; mean age 55±19 and 75±8 years, respectively), 44 eyes had discernible MNV (11 MMD-MNV and 33 AMD-MNV) on SS-OCTA at the time of the study and were included in the analysis. The MMD-MNV group exhibited a three-fold smaller sized MNV (p=0.001), lower greatest linear dimension (p=0.009) and greatest vascular caliber (p<0.001) compared to AMD-MNVs, and had a higher prevalence of tree-in-bud pattern. Eyes with AMD showed a higher prevalence of type 1 MNVs with medusa pattern. There was no difference in the location of the MNV, shape's regularity, margins, presence of core vessel, capillary fringe, peripheral loops, or perilesional dark halo (p>0.05) between both conditions. After adjustment, decreased MNV area and increased VD were associated with the tree-in-bud pattern, whereas the diagnosis did not significantly influence those parameters.

Conclusion:

While larger studies are warranted, this study is the first to describe and compare MMD-MNV and AMD-MNV using SS-OCTA, providing relevant clinical insight on MNV secondary to MMD and AMD. These findings also further validate OCTA as a powerful tool to detect and characterize MNV non-invasively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Ophthalmol Year: 2023 Document type: Article Affiliation country: United States Country of publication: New Zealand
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Ophthalmol Year: 2023 Document type: Article Affiliation country: United States Country of publication: New Zealand