Cutaneous and Visceral Leishmaniasis Caused by the Same Zymodeme of Leishmania donovani in Kerala, India.
Am J Trop Med Hyg
; 110(1): 59-63, 2024 Jan 03.
Article
in En
| MEDLINE
| ID: mdl-38109764
ABSTRACT
The tribal population in and around the Western Ghats region of India is affected by both cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) with typical clinical symptoms. In this study, we recorded and analyzed seven CL and three VL cases from this emerging belt. All the cases were found as autochthonous transmission. Multiple genetic markers (minicircle kinetoplast DNA polymerase chain reaction and restriction fragment length polymorphism of 3'untranslated region heat shock protein (HSP) 70, a larger segment of HSP 70, and 6-phosphogluconate dehydrogenase [PGDH] gene sequences) were used to identify and characterize the parasite. It was found that both clinical manifestations are caused by zymodeme MON-37 of Leishmania donovani. We have investigated the detailed entomological and epidemiological aspects of disease transmission. An abundant population of the proven vector Phlebotomus argentipes was observed in the study villages.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phlebotomus
/
Leishmania donovani
/
Leishmaniasis, Cutaneous
/
Leishmaniasis, Visceral
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Am J Trop Med Hyg
Year:
2024
Document type:
Article
Affiliation country:
India