IMMUNE-INFLAMMATORY-ENDOCRINE REGULATION DISORDERS IN CHILDREN WITH CORONAVIRUS INFECTION.
Wiad Lek
; 76(11): 2420-2428, 2023.
Article
in En
| MEDLINE
| ID: mdl-38112359
ABSTRACT
OBJECTIVE:
Theaim:
To study the of homeostasis links desorder and indicators imbalance in children with Coronavirus infection. PATIENTS ANDMETHODS:
Materials andmethods:
A clinical and laboratory study was conducted in children (50 persons) with Coronavirus infection. The children were used outpatient treatment.RESULTS:
Results:
It was found that Direct bilirubin was increased in 3 times (10.55±7.67 vs. 3.63±0.49 µmol/l, p<0.01), Alanine aminotransferase - in 1.7 times (37,02±20.53 vs. 21.90±1.82 IU/l, p<0.01). An levels increassng of Ig G - in 12.3 times, Ig E - in 4.6 times, Ig M - in 3.4 times was observed. The CRP level was increased in 3.1 times (8.76 ± 2.16 vs. 2.54 ± 0.53 mg/l, p< 0.01), C-peptide (4.65±1.67 vs. 1.23±0.08 ng/ml, p<0.01) - in 3.8 times. Negative correlations of T3 with Procalcitonin (r=-0.30) and Creatinine (r=-34) were revealed. T4 values are correlated with Total cholesterol (r=-0.65) and Creatinine (r=0.29). Leptin was presented positive correlations with Alanine aminotransferase (r=0.48) and with C-peptide (r=0.39).CONCLUSION:
Conclusions:
There was an increase in the Ig G levels in 12.3 times, Ig E - in 4.6 times, and the Ig M level - in 3.4 times. The Thyroid stimulating hormone level was significantly lower (in 4.7 times). An increase in the C-reactive protein levels (in 3.1 times) and C-peptide (in 3.8 times) was observed. It should be noted that the strongest negative correlation between T4 and Total cholesterol (r=-0.65) and the highest positive correlation between Leptin and Alanine aminotransferase (r=0.48) and C-peptide (r=0. 39).Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronavirus Infections
/
Leptin
Limits:
Child
/
Humans
Language:
En
Journal:
Wiad Lek
Journal subject:
MEDICINA
Year:
2023
Document type:
Article
Affiliation country:
Ukraine
Country of publication:
Poland