Brain metastases and next-generation anticancer therapies: a survival guide for clinicians.
Crit Rev Oncol Hematol
; 194: 104239, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38128629
ABSTRACT
Historically, patients with brain metastases (BMs) have been characterized by few systemic treatment options and poor prognosis. The recent introduction of next-generation anticancer therapies such as molecular targeted agents and immunotherapy have revolutionized the clinical decision-making process of this sub-population, posing new challenges to physicians. In this review, current evidence for the use of checkpoint inhibitors and targeted therapies in patients with BMs are discussed, with a focus on lung cancer, breast cancer, melanoma and renal cell carcinoma, providing suggestions and potential workflows for daily clinical practice. Several other on-going and future challenges, such as clinical trials design, ways to improve CNS penetration of novel drugs and unique molecular characteristics of BMs, are also discussed. The aim is producing an updated and easy-to-read guide for physicians, to improve decision-making in clinical practice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Kidney Neoplasms
/
Lung Neoplasms
/
Melanoma
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Crit Rev Oncol Hematol
/
Crit. rev. oncol. hematol
/
Hematology
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country:
Italy
Country of publication:
Netherlands